Research

I develop and apply computational methods to study mutation rate and spectrum evolution in mammalian genomes. Here are a few research questions I’ve pursued in the past:

How does inherited genetic variation impact the germline mutation rate?

Related paper: A natural mutator allele shapes mutation spectrum variation in mice

To what degree do mutation rates vary among human families?

Related paper: Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation

How do structural and single-nucleotide variants interact to promote rapid adaptation?

Related paper: Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays